Picking the Right Profession Combos
During gameplay, you can run into a profession trainer and he/she will teach you the ways of their talent. You can only choose 2 professions, and these are permanent, so choose very carefully. He is a little run down of how you should pick:
Skinning & Leather Working-You can skin monster you kill, then use the skin you get and make armor to sell or wear.
Mining & Blacksmiting- Mine minerals, then use them for armor, weapons and other items.(Mining good with engineering also)
Alchemist & Herbalist- Get plants from exploring, then use them to make potions.
Fishing & Cooking-Catch fish, then cook 'em and eat 'em!(Fishing goes with alchemy a little also)
Other professions arn't really combos with another profession.
Also, there are 3 specific professions that can be learned and they will not take up one of the two permanent slots. They are:
First Aid-Make Bandages and heal after battles.
Cooking-Cook your fish and such to get more health from them.
Fishing-Fish for free food!